La Salle 76, Mississippi 74 — Tyrone Garland banked home a scooping layup with two seconds left, vaulting the 13th-seeded Explorers past the Rebels and to their deepest run in the NCAA Tournament since they played for the championship in 1955.
Ramon Galloway had 24 points for La Salle (24-9), which was playing its third game in five days. No. 12 Ole Miss (27-9) led, 74-72, with 1:58 left, but failed to reach the regional semifinals for the first time since 2001.
After Tyreek Duren’s two foul shots tied it 74-all at the 1:07 mark, Marshall Henderson failed to hit an off-balance bank shot that would have given Mississippi the lead. Henderson had 21 points in a game with 11 lead changes. Duren had 19 points for La Salle and Garland had 17.
Murphy Holloway had 14 points for Mississippi, which fell one win shy of breaking the school record.
Duke 66, Creighton 50 — Rasheed Sulaimon scored 21 points, Seth Curry had 17, and the No. 2 Blue Devils held off the seventh-seeded Bluejays in Philadelphia.
A year after it lost its NCAA Tournament opener, Duke (29-5) is back in the regional semifinals for the 23d time. The Blue Devils will play No. 3 seed Michigan State (27-8) Friday in Indianapolis.
Mason Plumlee, Josh Hairston, and Ryan Kelly battled foul trouble all game that could have doomed the Blue Devils. But Creighton (28-8) went cold and never made a serious run in the second half. Doug McDermott scored 21 points but made only four baskets.
With McDermott slumping, the Bluejays were knocked out in the third round by an ACC team for the second straight season.