44. The Nutty Professor (1963)
Memorable quote: “Well, just don’t do something, sit there!”
Laugh factor: Speaking of the comedic genius of Jerry Lewis, how could this list be complete without perhaps his most significant onscreen role? Lewis was a comedian ahead of his time as a bookish professor who desperately wants to become a ladies’ man. When this movie was remade in 1996, plugging another legendary comedian, Eddie Murphy, into the lead role, it failed to bottle the magic of the original.
Watch the trailer