4. 'Final Fantasy: The Spirits Within' (2001)
Gross (Worldwide): $85,131,830
LOSS: - $94,434,085
Originality can go a long way in Hollywood, but gambling nearly $140 million on originality seems like the equivalent of playing Russian roulette -- which was pretty much the case with "Final Fantasy." The film, done completely in CGI, bankrupted its production company, Square Pictures.
(Text by James Duffy, Boston.com Correspondent)