ABC

(Top row) Isaiah Washington as Dr. Preston Burke, Chandra Wilson as Miranda Bailey, Sandra Oh as Cristina Yang, James Pickens Jr. as Dr. Richard Webber, Ellen Pompeo as Meredith Grey, and T.R. Knight as George O'Malley.

(Bottom row) Katherine Heigl as Isobel "Izzie" Stevens, Justin Chambers as Alex Karev, and Patrick Dempsey as Dr. Derek Shepherd.