HOLMES AND WATSON

2. House and Wilson, "House"

Wilson is the only person who truly understands and tolerates House. And Wilson is the only person House truly trusts. Last season, House (left) was irked by Wilson's (right) love affair with Amber, fretting like a jealous lover. Now, with their relationship in danger of ending, House is devastated.

Pictured: Hugh Laurie (left) as House and Robert Sean Leonard as Wilson.