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Solutions for the 'file-drawer' problem in science research

Posted by Kevin Hartnett  February 8, 2013 11:27 AM

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File Drawer.jpegOn Wednesday I wrote about growing skepticism among psychologists about the validity of behavioral priming. The controversy reflects more general critiques that have been made about research methods in psychology and other fields in recent years. Together, these critiques suggest that false-positives—when an experiment detects a causal relationship where none in fact exists—are published more often in academic journals than has been supposed.

One of the main problems that research watchdogs point to is something called the “file-drawer effect”—the tendency among researchers to publish their positive results while tucking their negative results in a drawer and forgetting about them.
This is problematic for a number of reasons. For one, negative results still contribute useful knowledge, even if they won’t make a researcher’s career. And two, it’s important to publish negative results as a check against false-positives (even a completely spurious experiment might turn up a false-positive one time in 100; but unless the negative results are also published, you wouldn't know to discount the positive result).

There are a number of proposals circulating that would address this problem. One, AllTrials, is a petition calling for all clinical trials to be registered in a central database before they begin. This would ensure that methods don’t change midstream and that negative results are made public. It would also prevent scenarios where an experiment is run a number of times but only the single positive result is submitted for publication. The AllTrials proposal is similar to decisions that two leading medical journals—The Lancet and the Journal of the American Medical Association—have made on their own, to only publish the results of experiments that are registered ahead of time.

The federal government has also recognized the dangers of the file-drawer effect. In 1997 the Food and Drug Administration Modernization Act established Clinicaltrials.gov, a database to which researchers are expected to post results of all clinical trials within a year of conducting them. The requirement is minimally enforced, however. A 2009 review of the database published in PLoS Medicine found major holes in the data posted to Clinicaltrials.gov and concluded that, as currently operated, the site is of “limited” value.

Image courtesy of American Libraries

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About brainiac Brainiac is the daily blog of the Globe's Sunday Ideas section, covering news and delights from the worlds of art, science, literature, history, design, and more. You can follow us on Twitter @GlobeIdeas.
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