8. Go after small companies
If you have been out of the market for quite some time, don't go after those big Fortune 500 companies. They will often have concerns about that "break" from work, especially when viewed against the hundreds of other applicants that have not had a break.
Small companies (from two to 50 employees) look at applicants completely differently. They will be more likely to value your quality of life, and also recognize they can't compete with the Fortune 500 companies. This is a great avenue for you to get back into the workforce. After a few years with a small shop, you can then market yourself to a larger firm.