'Joe Versus the Volcano' (1990)

On happiness:

Frank Waturi (played by Dan Hedaya, speaking to Joe Banks, played by Tom Hanks): "Do you think I feel good? Nobody feels good. After childhood, it's a fact of life. I feel rotten. So what? I don't let it bother me. I don't let it interfere with my job."

Pictured, Hedaya (left) with Hanks.