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The Sixteenth Annual 2005 Globe 100 | The Best of Massachusetts Business Index of coverage Globe 100 chart
1. Boston Scientific
2. Varian Semi Assoc.
3. Gillette Co.
4. Avid Tech
5. Investors Fncl
No. 6-10
Complete 2005 Globe 100 chart

Life sciences firms are kings of the hill
Aspen Technology endures profit plunge
NStar still delivers
State seeks a few good giants

Manufacturing
Retail
Real Estate
Medical Devices
Consumer Products
Employment
IPOs
Financial Services
Technology
Telecommunications
Services Cos.
The Bulls
The Bears

Globe 100 chart
Sales 100
Growth 50
Biggest profits
Biggest losses
The bulls
The bears
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Wall Street darlings

Ranked by ratio of market value to revenue.
RankCompany2004 revenue (millions)Market value (millions)Market value to revenue
1 Oxigene $0.0 $81.8 11,686.3
2 Sontra Medical Corp. $0.0 $25.7 756.7
3 Ariad Pharmaceuticals $0.7 $295.8 398.7
4 Wave Systems Corp. $0.2 $73.1 349.9
5 Acusphere $1.7 $96.5 56.3
6 Medwave $0.9 $39.4 41.9
7 Curis $5.0 $171.4 34.6
8 NitroMed $16.5 $523.8 31.8
9 Oscient Pharmaceuticals $6.6 $178.7 27.0
10 EPIX Pharmaceuticals $12.3 $162.6 13.3
NOTE: Company stock must have been traded on Dec. 31, 2004, with a price of $1 a share or higher, and company must have a market value of $1 million or higher.
SOURCE: Standard&Poor's Compustat
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