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The 18th Annual 2006 Globe 100 | The Best of Massachusetts Business Index of coverage Globe 100 chart
1. Akamai Inc.
2. American Science
3. Genzyme
4. Affiliated Managers
5. First Marblehead
No. 6-10
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Globe National 25

Publicly held companies not based in Massachusetts with a major presence in the state, ranked by 2005 composite performance.
2006CompanyComposite scoreReturn on average equity (%)Change in revenue (%)Change in profit margin (%)Revenue (billions)
1 Home Depot 9.5 22.9 11.5 4.7 $81.5
2 Lowe's Cos. 10.25 21.4 18.6 7.4 $43.2
3 Best Buy Co. 10.25 23.5 12.4 8.5 $30.8
4 Target Corp. 11.25 17.7 12.3 13.7 $52.6
5 IBM Corp. 11.5 24.7 -5.4 12.7 $91.1
6 Wal-Mart Stores 11.75 21.9 9.6 -0.1 $315.7
7 Procter & Gamble Co. 11.75 17.8 13.8 0.5 $61.7
8 United Parcel Service 11.75 23.3 16.4 -0.2 $42.6
9 Wyeth 12.25 33.5 8.1 174.2 $18.8
10 Federated Department Stores 12.5 13.9 41.9 40.4 $22.4
11 General Electric Co. 13 16.6 10.9 1.1 $148.0
12 Bank of America Corp. 14.25 16.3 10.9 6.4 $53.2
13 Adecco SA 14.25 23.3 6.2 28.5 $21.7
14 Manulife Financial Corp. 14.5 14.2 18.8 8.2 $27.5
15 Walgreen Co. 15.75 17.8 11.3 -2.7 $44.4
16 Fedex Corp. 15.75 16.8 9.9 8.6 $31.5
17 Brinker International 16.5 18.6 8.2 40.5 $4.0
18 Sovereign Bancorp 16.75 12.5 21.9 22.3 $2.1
19 Verizon Communications 17 19.2 5.4 -3.3 $75.1
20 Royal Bank of Scotland 17 15.6 10.7 0.3 $44.5
21 Sears Holdings Corp. 18 11.8 147.6 -65.4 $49.1
22 McDonald's Corp. 19.25 17.7 7.3 6.4 $20.5
23 Securitas AB 19.25 20.3 10.6 -3 $8.3
24 Fortune Brands 20.75 17.2 15.2 -13.2 $6.7
25 Whole Foods Market 21.25 12.5 21.5 -12.2 $5.0
SOURCE: Standard & Poor's Compustat
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