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The 18th Annual 2006 Globe 100 | The Best of Massachusetts Business Index of coverage Globe 100 chart
1. Akamai Inc.
2. American Science
3. Genzyme
4. Affiliated Managers
5. First Marblehead
No. 6-10
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Growth 50

Ranked by composite score, based on average annual revenue and profit growth for the past two years (ties broken by profit growth).
20052005CompanyScore2-year average annual revenue growth (%)2-year average annual income growth (%)
1 -- Anika Therapeutics 2.5 39.2 166.9
2 -- Palomar Medical Technologies 4 48 127.6
3 -- First Marblehead Corp. 5.5 90.8 93.9
4 2 Varian Semiconductor Equipment Associates 10 26.9 128.1
5 -- Moldflow Corp. 10 29.5 121.4
6 16 Hologic 11.5 22.9 142.4
7 50 Mac-Gray Corp. 11.5 32 71.4
8 -- Digitas 12 34.7 55.7
9 19 CRA International 13.5 35.4 47.4
10 31 Affiliated Managers Group 14 36.1 40.3
11 -- Applix 15 16.3 539.9
12 19 Charles River Laboratories International 17 35.2 33.1
13 -- EMC Corp. 18 24.5 51.1
14 20 LoJack Corp. 18.5 23.1 55.6
15 30 Boston Private Financial Holdings 18.5 27.5 45.7
16 7 Tech/Ops Sevcon 19.5 15.5 122.3
17 -- ADE Corp. 20.5 12.3 142.2
18 36 Psychemedics Corp. 21.5 15.6 82.3
19 -- Cognex Corp. 22 20.2 49.6
20 7 Forrester Research 26.5 10.3 127.6
21 17 Cytyc Corp. 26.5 29.5 22
22 22 HRPT Properties Trust 28 17.7 31.9
23 21 Bright Horizons Family Solutions 29 15 35.4
24 14 Investors Capital Holdings Ltd. 29 20.5 26.8
25 3 Boston Scientific Corp. 29 34.4 15.3
26 37 Lifeline Systems 30.5 14.1 33.3
27 13 Arrhythmia Research Technology 33.5 29.6 12
28 -- RSA Security 34 9.2 69.1
29 39 Eaton Vance Corp. 34.5 18.4 20.5
30 24 Progress Software Corp. 35.5 12.8 28.5
31 26 Watts Water Technologies 36 14.5 22.8
32 33 Staples 37.5 11.4 30.5
33 27 Iron Mountain 38 17.7 16
34 72 Raytheon Co. 38 10 32.7
35 59 Haemonetics Corp. 39 8.5 59.6
36 28 Mercury Computer Systems 40 23.4 8.6
37 31 Safety Insurance Group 40.5 6.5 82.8
38 23 Kronos 41 13.9 18.8
39 35 American Dental Partners 42 9.7 29
40 40 Investors Financial Services Corp. 43 9.2 31.5
41 70 National Dentex Corp. 43 17 11
42 89 Analogic Corp. 44 5.1 89.3
43 -- MRO Software 44.5 6.3 53.4
44 33 Dynamics Research Corp. 47.5 10.8 14.9
45 70 Thermo Electron Corp. 47.5 17.7 6.4
46 28 Providence and Worcester Railroad Co. 48.5 5.6 37.4
47 3 Candela Corp. 48.5 24.4 -4.5
48 41 Interactive Data Corp. 49 10.7 14
49 5 Avid Technology 50 28.2 -8.8
50 6 Commerce Group 51.5 7.2 23.1
NOTE: To be considered for the Growth 50, a company must have been publicly traded for two full years and must have reported profits in all periods. Score ties are broken by profit growth.
SOURCE: Standard & Poor's Compustat
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