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The 18th Annual 2006 Globe 100 | The Best of Massachusetts Business Index of coverage Globe 100 chart
1. Akamai Inc.
2. American Science
3. Genzyme
4. Affiliated Managers
5. First Marblehead
No. 6-10
Complete 2006
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Largest losses

Ranked by net income from continuing operations in 2005.
RankCompanyNet income (millions)1-year change(%)
1 Vertex Pharmaceuticals -$203.4 -22.4
2 Millennium Pharmaceuticals -$198.2 21.4
3 3Com Corp. -$143.8 7.9
4 American Tower Corp. -$134.1 43.9
5 NitroMed -$105.9 -255.5
6 Oscient Pharmaceuticals -$88.6 5.2
7 Five Star Quality Care -$81.2 -1,529.1
8 Cabot Corp. -$64.0 -151.6
9 LTX Corp. -$61.7 8.8
10 Praecis Pharmaceuticals -$61.2 -6.2
SOURCE: Standard & Poor's Compustat
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