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The 18th Annual 2006 Globe 100 | The Best of Massachusetts Business Index of coverage Globe 100 chart
1. Akamai Inc.
2. American Science
3. Genzyme
4. Affiliated Managers
5. First Marblehead
No. 6-10
Complete 2006
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Most profitable

Ranked by profit margin in 2005.
RankCompanyRevenue (millions)Net income(millions)Profit margin (%)
1 Pressure BioSciences $0.1 $0.9 823.6
2 Akamai Technologies $283.1 $328.0 115.9
3 TC Pipelines $53.2 $50.2 94.4
4 Apogee Technology $5.2 $3.0 57.1
5 First Marblehead Corp. $505.3 $196.4 38.9
6 ADE Corp. $104.0 $33.7 32.4
7 Hingham Institution for Savings $19.4 $6.2 31.8
8 Brookline Bancorp $70.9 $22.0 31.1
9 Massbank Corp. $23.6 $7.3 31.1
10 LSB Corp. $15.5 $4.2 26.9
SOURCE: Standard & Poor's Compustat
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