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The 18th Annual 2006 Globe 100 | The Best of Massachusetts Business Index of coverage Globe 100 chart
1. Akamai Inc.
2. American Science
3. Genzyme
4. Affiliated Managers
5. First Marblehead
No. 6-10
Complete 2006
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Top biotechnology companies

Ranked by 2005 revenue.
RankCompanyRevenue (millions)1-year change (%)
1 Genzyme Corp. $2,734.8 24.2
2 Biogen IDEC $2,422.5 9.5
3 Waters Corp. $1,158.2 4.9
4 Charles River Laboratories International $1,122.2 46.3
5 Millipore Corp. $991.0 12.2
6 Sepracor $820.9 115.5
7 Millennium Pharmaceuticals $558.3 24.6
8 BrukerBioSciences Corp. $297.6 4.6
9 Vertex Pharmaceuticals $160.9 56.6
10 Alkermes $136.0 96.6
SOURCE: Standard & Poor's Compustat
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