2010 Globe 100 - The Best of Massachusetts Business

Net income nosedives

Ranked by one-year change in net income.
Rank Company 2009 Net income (millions) 2008 Net income (millions) Change (millions)
1 State Street Corp. -$1,881.0 $1,811.0 -$3,692.0
2 Hologic -$2,198.1 $11.1 -$2,209.3
3 MKS Instruments -$212.7 $30.1 -$242.8
4 Alkermes -$39.3 $125.8 -$165.0
5 Cabot Corp. -$52.0 $54.0 -$106.0
6 Aspen Technology -$33.4 $59.3 -$92.7
7 Newstar Financial -$44.3 $22.4 -$66.7
8 Infinity Pharmaceuticals -$32.5 $23.7 -$56.2
9 Varian Semiconductor Equipment Associates -$7.8 $41.8 -$49.6
10 Airvana -$25.0 $21.3 -$46.3
SOURCE: Capital IQ, a Standard & Poor's business