Net worth: $1.5 billion
Overall rank: 974
Ragon founded InterSystems in 1978 and built it to a $443 million company. He and his wife, Susan, have established the Ragon institute with Mass General Hospital, Harvard, and MIT, to pursue the development of an HIV vaccine, Forbes reported.
Shown: Phillip and Susan M. Ragon, center, tour the MGH lab in Charlestown of Dr. Bruce Walker in 2009.