Net worth: $1.5 billion
Overall rank: 352
Ragon founded InterSystems in 1978 and built it to a company that posted $443 million in revenues in 2012. He and his wife, Susan, have established the Ragon Institute of Massachusetts General Hospital, Harvard, and MIT, to pursue the development of an HIV vaccine, Forbes reported.
Shown: Phillip and Susan M. Ragon, center, toured the MGH lab in Charlestown of Dr. Bruce Walker in 2009.