I think it is premature to panic. With Oritz hurting I don't think this team is going to score a ton of runs. They do need to remedy the rightfield situation. Ellerby in my opinion deserves a least a platoon opportunity with Drew. He would also settled the leadoff situation, which has also been a weakeness all year.
The Gagne issue is complicated. If he has another outing like today the team is going to have to use him differently. Maybe in the seventh to start an inning and go with a combo of Lopez, Timlin and Delcarmen. Okijima and Papelbon for the 8th and 9th seems like the way to go.
The starting pitching on this team is a definite strength and Lowell, Youks, and Pedroia have played well this year.
If the Sox can resolve this current middle-inning relief dilemma that they have now they should be in fine shape. They may lose the Division but I wouldn't count this team out.