The Globe 100's top midsized employers
All of the participating companies were placed into one of three size bands, based on the number of employees in Massachusetts. Small workplaces were defined as those with 100 to 249 employees; midsized workplaces were defined as those with 250 to 999 employees; and large workplaces were companies with 1,000 or more workers. More on the methodology.

- Charts Top 100 overall
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- By Size Small
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- Midsized
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- Large

| Overall rank | Size band rank | Company | Description | Size | Mass. employees | Total US employees | US headquarters | 2008 revenue |
| 3 | 1 | Harmonix Music Systems | Video game developer | Midsize | 272 | 315 | Cambridge | $1 billion |
| 6 | 2 | Commonwealth Financial Network | Financial services | Midsize | 416 | 460 | Waltham | $508 million |
| 8 | 3 | Analysis Group | Economic consultant | Midsize | 250 | 444 | Boston | NA |
| 10 | 4 | Software | Midsize | 200+ | 19,665* | Mountain View, Calif. | $21.8 billion | |
| 15 | 5 | Aviv Centers for Living | Senior care | Midsize | 425 | 425 | Swampscott | $27 million |
| 18 | 6 | TechTarget | Technology media | Midsize | 450 | 530 | Needham | $105 million |
| 21 | 7 | Bingham McCutchen | Law firm | Midsize | 608 | 2,250 | Boston | $767 million |
| 22 | 8 | Christian Book Distributors | Book sales | Midsize | 500 | 500 | Peabody | NA |
| 25 | 9 | Starent Networks Corp. | Mobile networking | Midsize | 298 | 350 | Tewksbury | $254 million |
| 26 | 10 | BBN Technologies | Research and development | Midsize | 503 | 743 | Cambridge | NA |
| 29 | 11 | Education Development Center | Education nonprofit | Midsize | 412 | 709 | Newton | $145 million |
| 34 | 12 | Dassault Systemes SolidWorks Corp. | CAD software | Midsize | 387 | 390 | Concord | $407 million |
| 37 | 13 | Cubist Pharmaceuticals | Pharmaceuticals | Midsize | 359 | 575 | Lexington | $434 million |
| 38 | 14 | Hill Holliday | Advertising firm | Midsize | 407 | 820 | Boston | NA |
| 41 | 15 | Enterprise Bank | Community bank | Midsize | 318 | 338 | Lowell | $48 million |
| 42 | 16 | e-Dialog | E-mail marketing | Midsize | 270 | 330 | Burlington | $105 million |
| 47 | 17 | Vistaprint | Small-business marketing | Midsize | 475 | 475 | Lexington | $401 million |
| 55 | 18 | Cell Signaling Technology | Research techology | Midsize | 271 | 281 | Danvers | $73 million |
| 56 | 19 | Microsoft Corp. | Software | Midsize | 872 | 56,552 | Redmond, Wash. | $60.4 billion |
| 57 | 20 | FLIR Systems | Imaging systems | Midsize | 292 | 1,300 | Wilsonville, Ore. | $1.1 billion |
| 60 | 21 | Wequassett Resort and Golf Club | Resort | Midsize | 325 | 325 | Harwich | $17 million |
| 62 | 22 | Employ+Ability | Medical devices | Midsize | 261 | 261 | Braintree | $12 million |
| 63 | 23 | Cambridge Associates | Investment consultant | Midsize | 443 | 890 | Boston | NA |
| 64 | 24 | Brightview Senior Living | Senior living | Midsize | 300 | 1,900 | Baltimore | $89 million |
| 65 | 25 | HarborOne Credit Union | Credit union | Midsize | 350 | 350 | Brockton | $98 million |
| 66 | 26 | Suffolk Construction Co. | Construction | Midsize | 403 | 724 | Boston | $1.6 billion |
| 71 | 27 | Millennium: The Takeda Oncology Company | Biotechnology | Midsize | 959 | 1,228 | Cambridge | $591 million |
| 75 | 28 | Vanasse Hangen Brustlin | Consulting services | Midsize | 366 | 850 | Watertown | $147 million |
| 81 | 29 | Eaton Vance | Financial services | Midsize | 764 | 842 | Boston | $1.1 billion |
| 85 | 30 | South Shore YMCA | Human services | Midsize | 800 | 877 | Quincy | $20 million |
| 87 | 31 | Natixis Global Associates | Financial services | Midsize | 251 | 1,612 | Boston | NA |
| 95 | 32 | Salter Healthcare | Health care | Midsize | 700 | 700 | Winchester | $41 million |
| 97 | 33 | American Student Assistance | Financial aid | Midsize | 637 | 665 | Boston | $139 million |
| 98 | 34 | Wilmer Cutler Pickering Hale & Dorr | Law firm | Midsize | 850 | 2,370 | Washington, D.C., Boston | $955 million |
| 100 | 35 | CDM | Engineering consultants | Midsize | 726 | 3,715 | Cambridge | $1 billion |

