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White Coat Notes

Journal reviewer tipped off drug firm before publication

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February 4, 2008

Excerpts from the Globe's blog on the Boston-area medical community.

A peer reviewer for the Waltham-based New England Journal of Medicine leaked a negative article about a diabetes drug to its manufacturer more that two weeks before the study appeared, another major scientific journal reported last week. Dr. Steven Haffner of the University of Texas Health Science Center at San Antonio faxed his copy of a report on Avandia to drug maker GlaxoSmithKline 17 days before the article was published online on May 21, 2007, according to the new story in Nature.

"Why I sent it is a mystery," Haffner told Nature. "I don't really understand it. I wasn't feeling well. It was bad judgment."

Nature's own embargo on the story was broken when US Sen. Charles Grassley, R-Iowa, made public a letter demanding answers from GlaxoSmithKline on the leak.

Less invasive surgery better for aneurysm repairs
Older patients fare better when weaknesses in their largest blood vessel are repaired endoscopically rather than surgically, a Harvard study reports. The benefit of endoscopy relative to open surgery is greater the older the patient is, and it remains years after the procedure, the study found.

Abdominal aortic aneurysms can be patched before they rupture with fabric-covered metal stents threaded through arteries - a procedure called endoscopy - or they can be repaired during an operation that cuts through the abdominal wall. Randomized trials in Europe have shown that older people survived the less invasive surgery better than open operations, but the rate of repeat procedures needed to shore up the repair was higher in the endoscopic group.

"This shows for the older age group, there's no question they should have the endoscopic stent," said Dr. Marc L. Schermerhorn of Harvard Medical School, an author of the New England Journal of Medicine article.

Local grant winners
Management Sciences for Health, a private nonprofit based in Cambridge, has received a three-year, $2.8 million grant from the Bill & Melinda Gates Foundation to build programs in East Africa to improve access to medicines.

Fenway Community Health has won a $1.75 million challenge grant from the Kresge Foundation to help it build a new health and research center. Fenway, which specializes in the health of lesbian, gay, bisexual, and transgender people, must raise $6 million toward its goal of $18 million by July 2009 to receive the Kresge grant, which would be the largest in the health center's history.

Northeastern University professor Mansoor Amiji has been awarded a four-year, $1.34 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases to study a potential treatment for inflammatory bowel disease.

ELIZABETH COONEY

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