A 22-year-old woman from Walpole died at the scene of a single-car crash on the southbound lanes of I-95 in Needham early Saturday morning, State Police said.

Framingham troopers responded to the incident at 2:15 a.m. The woman, identified as Sally C. White, was driving a 2004 Honda Civic and struck the side of a train bridge near Kendrick Street, before exit 19B, according to a statement from State Police. White was the only occupant of the vehicle.

Needham fire and EMS, the Massachusetts Department of Transportation, and other State Police agencies assisted in the response.

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State Police Framingham Barracks are investigating the cause of the fatal crash, said Dustin Fitch, a state trooper and spokesman.