THIS STORY HAS BEEN FORMATTED FOR EASY PRINTING

Cholesterol drug’s new potential is questioned

By Duff Wilson
New York Times / March 31, 2010

E-mail this article

Invalid E-mail address
Invalid E-mail address

Sending your article

Your article has been sent.

  • E-mail|
  • Print|
  • Reprints|
  • |
Text size +

NEW YORK — With the government’s blessing, drug giant AstraZeneca is about to expand the market for its blockbuster cholesterol medication Crestor to a new category of customers: as a preventive measure for millions of people who do not have cholesterol problems.

Some medical specialists question whether this is a healthy move.

They point to mounting concern that cholesterol medications — known as statins and already the most widely prescribed drugs in the United States — may not be as safe a preventive medicine as previously believed for people who are at low risk of heart attacks or strokes.

Statins have been credited with saving thousands of lives every year with relatively few side effects, and some doctors endorse the drug’s broader use. But for healthy people who would take statins largely as prevention — which would be the case for the new category of Crestor patients — other specialists suggest the benefits may not outweigh the potential side effects.

Among the risks raising new concerns, recently published evidence indicates that statins could raise a person’s risk of developing Type 2 diabetes.

“It’s a good thing to be skeptical about whether there may be long-term harm from healthy people taking a drug like this,’’ said Dr. Mark A. Hlatky, a professor of cardiovascular medicine at Stanford medical school.

In addition, the blood test being used to identify the new statin candidates measures the degree of inflammation in the body, but there is no consensus in that inflammation is a direct cause of cardiovascular problems.