Moderator Tim Russert asked about Republican presidential hopeful Rudy Giuliani's pledge to set back Iran by eight to 10 years if it tries to gain nuclear standing.

Senator Joe Biden of Delaware flashed anger at the mention of the former New York mayor. "Rudy Giuliani doesn't know what the heck he's talking about," he said. "He's the most uninformed person on foreign policy that's now running for president."