Other Cabinet secretaries who have talked about leaving are Attorney General Eric Holder and Transportation Secretary Ray LaHood, the only Republican in the Cabinet. Both have said they would speak with the president before making a final decision.
Second term shake-ups are also sure to hit Obama’s West Wing inner circle. Plouffe is expected to be among those departing, while Obama’s senior adviser and close friend Valerie Jarrett is staying on.
And if Obama taps Lew for the Treasury Department, he'll have to add chief of staff to the list of vacancies
Associated Press writers Martin Crutsinger, Ben Feller, Ken Thomas and Pete Yost contributed to this report.