Hawaii made a short side trip a long day for No. 4 Michigan State.
Matt Lojeski and Julian Sensley each scored 20 points for the Rainbow Warriors in an 84-62 victory in Honolulu that ended the Spartans' streak of season-opening wins at 28.
Michigan State, the first member of the preseason Top 10 to lose this season, was hampered by poor shooting and leg cramps. The Spartans stopped off on Oahu on the way to Maui Invitational that starts tomorrow and will see them play three games in as many days.
It was the biggest home win for the Rainbow Warriors (1-0) since they beat No. 2 Kansas in the finals of the 1997 Rainbow Classic.
Lojeski was 6 for 8 from 3-point range and his last one capped a 14-2 run that gave Hawaii a 70-52 lead with 6:03 left.
Maurice Ager had 16 points for the Spartans, but he was one of four Michigan State players affected by leg cramps.
Paul Davis, who had 12 points and 11 rebounds, left the game for a second and final time with cramps with 13:27 to play. Ager, Shannon Brown, and Drew Neitzel all had to leave the game at some point because of the cramps. Brown had to be removed on a stretcher with 6:36 left because of the intense pain.
UC Irvine 79, Stanford 63 -- Ross Schraeder scored 19 points and the visiting Anteaters used an impressive shooting performance and hustle to shock the No. 13 Cardinal in their opener.
Darren Fells added 18 points, 9 rebounds, 5 assists, and 2 blocks for UC Irvine (2-1), which beat Stanford for the first time in six meetings.
Duke 84, Davidson 55 -- J.J. Redick started a rally late in the first half and finished with 29 points, leading the top-ranked Blue Devils (3-0) past the visiting Wildcats.
Oklahoma 68, Samford 41 -- Kevin Bookout scored 13 points and grabbed 10 rebounds and Michael Neal added 15 points on five 3-pointers to help the No. 6 Sooners (1-0) pound the visiting Bulldogs.
Louisville 78, Tenn.-Martin 61 -- Juan Palacios had 16 points and 11 rebounds to lead the No. 7 Cardinals past the visiting Skyhawks. The win was the 450th at the college level for Louisville coach Rick Pitino, who's also coached at Boston University, Providence, and Kentucky.
Harvard 65, Vermont 57 -- Brian Cusworth scored 17 points and grabbed 10 rebounds and Jim Goffredo added 15 points, leading the Crimson past the visiting Catamounts in the opener for both teams. Vermont's Ryan Schneider had a career-high 19 points, and led both teams in scoring.
Rhode Island 56, Sacred Heart 50 -- Jamaal Wise scored a game-high 13 points and blocked a shot late in the game to help the host Rams hold off the Pioneers in the opener for both teams.
Quinnipiac 64, UNH 62 -- Adam Gonzalez's driving layup in the final second lifted the Bobcats (1-1) over the Wildcats (0-2) in the consolation game of the Tyler Ugolyn-Columbia Classic in New York. Blagoj Janev led New Hampshire with 17 points.
High Point 70, Maine 67 -- Jon Sheets scored 22 points but the Black Bears (0-2) dropped the consolation game of the William & Mary Tip-Off Classic in Williamsburg, Va.
Nebraska 73, Yale 64 -- Wes Wilkinson came off the bench to score 14 points and the Cornhuskers (2-0) beat the Bulldogs (1-1) in the John Thompson Basketball Challenge in Lincoln, Neb.
Baylor 74, Indiana 62 -- Sophia Young had 19 points and 16 rebounds, leading the defending NCAA champion and sixth-ranked Bears (3-0) over the host Hoosiers.
Stanford 69, LIU 28 -- Brooke Smith had 15 points and six rebounds to lead the 11th-ranked Cardinal to a season-opening victory over the Blackbirds in the semifinals of the Subway Classic tournament in Minneapolis.
Minnesota 80, San Francisco 62 -- Natasha Williams had 26 points and five blocks to help the No. 16 Gophers (1-0) rebound from a sluggish start to beat the Dons in the Subway Classic.
Harvard 69, Alabama St. 56 -- Laura Robinson and Jessica Holsey each scored 18 points to lead the Crimson (1-1) in the consolation game of the DePaul Invitational in Chicago.
Brandeis 73, Bates 62 -- Tournament MVP Caitlin Malcolm scored 21 points and the Judges (2-0), ranked No. 8 in the d3hoops.com poll, downed the 17th-ranked Bobcats (1-1) in the title game of the Brandeis Tip-Off Tournament in Waltham.