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Yankees slugger Gary Sheffield hit his 452d home run, tying Carl Yastrzemski for 27th all time.

Astros starter Brandon Backe left after only two innings because of a sprained right elbow.

Cardinals closer Jason Isringhausen gave up his second homer in four games. He allowed only four in 59 innings last season and entered the season trailing only Mariano Rivera for fewest homers allowed since 2000 with 22 in 382 innings.

Moises Alou became the first Giants player to hit his 300th homer since Barry Bonds in 1996.

Oakland's Dan Johnson is 0 for his last 25.

San Diego's Dewon Brazelton drove in a run with his first major league hit, a two-out double that made him 1 for 22 lifetime.

Jimmy Rollins's 14th career leadoff homer tied Juan Samuel's Phillies record.

Cardinals center fielder Jim Edmonds had the first two-error game of his career.

The Dodgers are 29-9 against the Pirates since 2001, and are 14-5 at PNC Park.

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