The Chicago White Sox right-hander walked Boston leadoff batter Mike Aviles in the first inning Thursday night and yielded a one-out single to Dustin Pedroia in his first start since pitching a perfect game in a 4-0 victory at Seattle on Saturday.

Pedroia's dribbler up the third-base line was the first hit off Humber since Nick Markakis' one-out double for Baltimore in the fifth inning of the Orioles' 10-4 victory at Chicago on April 16.

Johnny Vander Meer remains the only major league pitcher to throw consecutive no-hitters, accomplishing the feat in 1938 with Cincinnati.

Adrian Gonzalez followed Pedroia with an RBI double, and David Ortiz added a run-scoring single to give the Red Sox a 2-0 lead.