Astros beat Cubs 1-0 win
It was an otherwise tough night for the second baseman, who committed three errors. Paredes has started the last three games at second base with All-Star Jose Altuve out with an abdominal strain.
Houston starter Jordan Lyles (4-11) scattered two hits and struck out five in five innings and five relievers completed the shutout. Wilton Lopez allowed two hits in a scoreless ninth for his fourth save.
The last error by Paredes came in the seventh inning, and interim manager Tony DeFrancesco lifted him for Altuve to start the eighth.
Cubs starter Justin Germano (2-7) allowed three hits and tied a career high with eight strikeouts. He lost his fifth straight start.
Paredes singled with one out in the third before Fernando Martinez reached on an error by catcher Steve Clevenger when he threw the ball over the head of first baseman Bryan LaHair.
Brett Wallace walked to load the bases and Houston took the lead on a sacrifice fly by Justin Maxwell.
The Cubs went 0 for 10 with runners in scoring position to break a season-high-tying four-game winning streak.
Two walks and a single by LaHair loaded the bases for the Cubs with one out in the second. They came away empty when Germano grounded into a forceout that left Clevenger out at home before Lyles struck out David DeJesus.
Another missed opportunity came in the sixth when Starlin Castro singled before a one-out double by pinch-hitter Dave Sappelt. But pinch-hitter Darwin Barney was out on a fly ball to Maxwell in center field and his throw to third beat Sappelt for the double play.
Cubs slugger Anthony Rizzo was injured in the third inning in a collision with Brett Wallace. Rizzo hit a grounder to Paredes in the third inning, and his throw to first was high, causing Wallace to jump to try and catch it. Rizzo collided with Wallace while he was in the air and tumbled violently to the ground.
He remained on the dirt for a minute while trainers looked at him. He finally sat up and slowly walked off the field with the help of the trainers. He has a sore right shoulder and upper back and the Cubs are going to monitor him for the next couple of days.
NOTES: Houston activated SS Jed Lowrie before Monday night's game, but he did not play. He has been on the DL since July 15 with an injured nerve in his right leg. ... Castro had an error in the eighth inning, his 24th of the season, which is the most among NL shortstops.