The base runners were cautious, waiting to see if Jennings would catch the ball in center. But it was well over his head.
After Daniel Nava was hit by a pitch, Will Middlebrooks hit a ball up the middle that Cobb grabbed. It should have been a double play but the pitcher slipped and was able only to get an out at the plate on a close play.
Drew was next and he grounded to first base. James Loney fired to second for the second out. But the return throw from shortstop Yunel Escobar was wild.
Two runs scored on the play. Cobb allowed only one other hit before leaving with two outs in the seventh inning.
The Sox added a run in the eighth when Pedroia (3 for 4) doubled and scored on a sacrifice fly by Middlebrooks.
Ryan Dempster gets the unusual 11:05 a.m. Patriots Day start Monday as the Sox seek a sweep.
“I wish Clay had done it,” Saltalamacchia said. “But we can’t complain with the way we’ve been playing.”