CHICAGO — The Red Sox didn’t get their first hit until the seventh inning on Tuesday night. A few swings later, they had the go-ahead run at the plate.
But the only solace in this game was avoiding the wrong end of history. The Red Sox could not take advantage of their late-inning chances and were beaten, 3-1, by the Chicago White Sox.
Felix Doubront (3-2) allowed two runs over six innings but was topped by Jose Quintana (3-1), who carried a no-hitter into the seventh inning and did not allow a run.
The Sox left four runners on base in the final three innings against the Chicago bullpen, three in scoring position. Addison Reed finished for his 16th save.
All nine runs the White Sox scored in the series have come with two outs, as have 13 of their 15 hits. Alex Wilson gave up a run in the eighth inning, only the second run the Red Sox bullpen has allowed in the last eight games.
The Red Sox are 5-3 on a road trip that ends Wednesday night. Clay Buchholz will pitch for the Red Sox against Hector Santiago. Chicago ace Chris Sale was scratched from the game because of a sore shoulder.
Dustin Pedroia drove in the only run for the Red Sox. But he was 0 for 4 and his hit streak ended at 12 games.
The Red Sox went 6⅓ innings without a hit. Quintana walked Daniel Nava in the second inning and Jacoby Ellsbury in the sixth. That was it for offense until the seventh inning.
The Red Sox were last no-hit in 1993 by Seattle’s Chris Bosio. Quintana was hardly overpowering but he was getting quick outs on routine plays.
As the crowd of 21,984 started to buzz about the no-hitter, Pedroia popped up to third base to bring Quintana eight outs away. But David Ortiz broke his bat on a 1-and-2 curveball and singled into center field.
Mike Napoli and Nava followed with singles to load the bases with one out. That was it for Quintana, who threw 107 pitches.
Righthander Jesse Crain ended the inning by striking out Middlebrooks on a full-count slider and Drew on a 2-and-2 changeup.
In two career starts against the Red Sox, the 24-year-old Quintana has thrown 14⅓ scoreless innings on eight hits with two walks and seven strikeouts.
Doubront nearly matched Quintana in the early innings, shutting the White Sox out for the first four innings on one hit.
Alexei Ramirez singled in the first inning and was quickly erased when Alex Rios grounded into a double play. The White Sox didn’t get another runner on base until the fourth inning when Alejandro De Aza drew a walk. Ramirez then grounded to first and Napoli started a double play.
Doubront got two outs in the fifth inning before Dayan Viciedo reached on a single through the shortstop hole that third baseman Will Middlebrooks was unable to make a play on.
The next pitch was an 89 mile-per-hour fastball to Jeff Keppinger that was belt high down the middle of the plate. Keppinger drove it into the bleachers in left center field for his first home run of the season.
Tyler Flowers followed with a single but Doubront ended the inning by getting Tyler Greene to ground to third base.
Rios walked with two outs in the sixth inning. Doubront then walked Paul Konerko before getting Adam Dunn on a fly ball to deep right field.
Doubront gave up two runs on five hits over six innings, throwing 56 of his 86 pitches for strikes. The lefthander has allowed four earned runs on eight hits over 11 innings in his last two starts and struck out 10. That has dropped his earned run average from 6.40 to 5.61.
The Sox threatened again in the eighth inning. Jarrod Saltalamacchia drew a walk off lefthander Matt Thornton before Ellsbury singled. When White Sox manager Robin Ventura called in righthander Matt Lindstrom.
Mike Carp, hitless in his last 16 at-bats, pinch hit for Jonny Gomes. He popped out to left field.
After a wild pitch moved the runners over, Pedroia grounded to shortstop. The ball went through the legs of Ramirez and Saltalamacchia scored.
Ortiz then grounded to Konerko at first base and he started a double play that ended the inning.Peter Abraham can be reached at email@example.com. Follow him on Twitter @PeteAbe.