As a member of the Colorado Rockies in 2007, Morales faced the Red Sox in the World Series twice. In Game 1, Morales started the fifth inning in relief of Jeff Francis and the Sox lit him up to the tune of 6 hits and 7 runs in 2/3 of an inning as Boston crushed Colorado 13-1 at Fenway Park. Kevin Youkilis, David Ortiz, Manny Ramirez, and J.D. Drew all drove in runs off Morales in the fifth inning.
In Game 3 at Coors Field, Drew doubled off Morales, the only hit Morales would give up in 2 1/3 innings, but the Red Sox cruised to a 10-5 victory.
Morales has appeared in 8 postseason games, with no record, and a 7.82 ERA.