Coco Crisp just homered into the Monster Seats, taking Angels' starter Joe Saunders deep for a two-run shot that rallied the Sox within 3-2 with no outs in the bottom of the sixth.
It was Crisp's first homer of the season at Fenway Park and first since June 17 at Philadelphia.
After Dustin Pedroia flied to center, Kevin Youkilis, who fouled one off his left foot in his first at-bat, showed no side effects when he laced a double off the wall in left, prompting Angels pitching coach Mike Butcher to make a mound visit.
After Youkilis advanced to third on Ortiz's ground out, Manny drew an intentional walk and Mike Lowell ended the inning by flying to right, leaving the tying run in Youkilis stranded at third.
After five innings, it's Angels, 3-2.