Brendan Harris tripled into the right field corner in the fourth inning to score Delmon Young and Craig Monroe, giving the Twins a 2-1 lead. Nick Punto singled to score Harris and add another run. All three runs came with two outs.
Monroe reached on a fielder's choice and Young reached on a single.
The runs end a streak of 12 consecutive scoreless innings for Red Sox starter Jon Lester.