David Ortiz got the night off because of a "tender, stiff" left wrist, according to Terry Francona.
"I'd like to play him every single day because he's a big threat, but I think we both thought it was the right day not to play," Francona said.
Ortiz felt a clicking in the wrist while the team was in Kansas City last week. Ortiz is expected to return to the lineup Tuesday night in Boston,
With Ortiz out, J.D. Drew served as the designated hitter. Drew had been a DH in just seven games in his career, including one this season, and a pinch hitting spot in 2007,
Kevin Youkilis was back in the lineup, though he apparently is still feeling that impingement in his left shoulder.