July 23 -- Red Sox 6, Indians 2
Not quite as storybook as his start in Game 4 of the World Series, but a necessary step to get Jon Lester there. After months of treatment, rehab, and toiling in the minor leagues, Lester was brought to Cleveland for his first start since being diagnosed with cancer in late August 2006. And he made it a good one. Lester threw six innings, allowing two runs on a Grady Sizemore home run, in a 6-2 win.