Associated Press

Hector Santiago allowed two hits in five-plus innings filling in for Jake Peavy Thursday night, Tyler Flowers hit a three-run homer, and the Chicago White Sox beat Texas, 3-1, in Arlington, handing the Rangers their first series loss of the season.

Flowers’s drive just inside the foul pole in left field was the third straight hit after Texas righthander Justin Grimm (2-1) retired 10 in a row on the day he was named AL rookie of the month.

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Adrian Beltre’s homer in the second was the only hit through five innings against Santiago (1-1), who had six strikeouts and two walks in 5 innings. The lefthander made his first start of the season and fifth of his career after Peavy was scratched because of back spasms.

Addison Reed pitched around two of Chicago’s eight walks, striking out the side in the ninth for his 10th save and second in two nights.

The coldest May game at Rangers Ballpark came just three weeks after the coldest day game there — and the Rangers lost both.

The game-time temperature of 44 was 37 degrees cooler than the previous night. It was a 40-degree difference April 10, when the temperature at first pitch was 39 degrees for 2-0 loss to Tampa Bay in a day game after it had been 79 the night before.

Orioles 5, Angels 1 — Chris Tillman returned to his hometown and outpitched Joe Blanton with eight scoreless innings of three-hit ball, right fielder Nick Markakis threw out Mike Trout at the plate, and visiting Baltimore dominated Los Angeles in the opener of a four-game series.

Padres 4, Cubs 2 — Yonder Alonso’s two-out fly ball to right field dropped in front of Julio Borbon for an RBI single that led to a four-run eighth inning and boosted San Diego over Chicago for a four-game series split at Wrigley Field.

Nationals 3, Braves 1 — Dan Haren pitched eight sharp innings, Denard Span hit a two-run double, and visiting Washington beat Atlanta.

Phillies 7, Marlins 2 — Ryan Howard and Domonic Brown hit solo homers to back Kyle Kendrick and host Philadelphia routed Miami.

Cardinals 6, Brewers 5 — Jake Westbrook allowed one run over six innings for his 100th career win and visiting St. Louis held off Milwaukee.

Tigers 7, Astros 3 — Don Kelly had an RBI single to start a four-run 14th inning to help visiting Detroit outlast Houston. The Tigers tied it in the eighth with help from right fielder Rick Ankiel’s error.

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The Royals’ game against the Tampa Bay Rays in Kansas City was postponed after heavy rain turned to sleet and snow during the middle of the fourth inning.

No makeup date was set.