No. 23 Washington at No. 2 Oregon

The Ducks have won the last eight meetings, the longest win streak for either side in a series that dates to 1900. The Huskies’ defense (ranked second in the Pac-12) will be tested by an Oregon offense that is putting up more than 52 points and 550 yards in total offense per game.

No. 3 Florida State vs. N.C. State

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A win would put the Seminoles firmly in the driver’s seat in the Atlantic Division. The Wolfpack are expected to start their fourth different offensive line combination in front of QB Mike Glennon this season (N.C. State has given up an ACC-worst 16 sacks this season).

No. 4 LSU at No. 10 Florida

The Tigers sputtered on offense the last two weeks, staving off Auburn (12-10) and then coming from behind to beat Towson (38-22), but Gators coach Will Muschamp believes those games were more fluke than trend. ‘‘We won’t see the same LSU football team,’’ he said.

No. 5 Georgia at No. 6 South Carolina

It’s a key game in the SEC’s Eastern Division, though the Bulldogs showed last year it was possible to rebound after a 45-42 home loss to the Gamecocks. This is the ’ first meeting with both teams ranked in the top 10.

Kansas at No. 7 Kansas State

The Wildcats are 24-point favorites in the Sunflower Showdown. The Jayhawks have forced 13 turnovers through four games, leading the Big 12 and tied for fifth nationally.

No. 8 West Virginia at No. 11 Texas

The Longhorns’ ninth-ranked scoring offense (47.2 points) looks meager compared with the Mountaineers’ third-ranked attack (53 per). Texas has surrendered five TDs of 44 yards or longer this season; West Virginia’s Geno Smith had four TD passes of 39 yards or longer in the second half against Baylor last weekend.

Miami at No. 9 Notre Dame

The Fighting Irish are trying to improve to 5-0 for the first time since 2002. Their strong pass defense will be challenged by the Hurricanes’ 15th-ranked aerial game. Notre Dame is the only FBS team that has not trailed this season.

No. 21 Nebraska at No. 12 Ohio State

This is the first meeting with both teams in the national polls. A year ago, the Buckeyes couldn’t hold a 27-6 lead in the third quarter and the Cornhuskers ran off the final 28 points to win, 34-27.

No. 14 Oregon State vs. Washington State

The Beavers are off to their best start since 2002 and at 3-0 have already matched their win total from last season.

Georgia Tech at No. 15 Clemson

The scuffling Yellow Jackets (coming off a loss to Middle Tennessee) ended the Tigers’ unbeaten run last year with a 31-17 victory in Atlanta Oct. 29.

Iowa State at No. 15 TCU

Redshirt freshman Trevone Boykin is the likely starter at QB for the Horned Frogs, in place of the suspended Casey Pachall, who is fifth nationally in passing efficiency.

No. 17 Oklahoma at Texas Tech

The Sooners want to avenge a loss to the Red Raiders last season that broke their 39-game win streak in Norman.

Arizona at No. 18 Stanford

The Cardinal have the No. 1 run defense in the conference and third best in the nation, allowing 65.2 yards rushing per game. Wildcats sophomore Ka’Deem Carey is averaging 107.6 yards rushing, 18th in the country.

No. 20 Mississippi State at Kentucky

The Bulldogs haven’t started 5-0 since 1999. This will be the Wildcats’ third straight ranked opponent.

UConn at No. 22 Rutgers

Kyle Flood is attempting to become the second coach in Scarlet Knights history to start 5-0. The Huskies have the nation’s sixth-best run defense (74.2 yards).

No. 24 Northwestern at Penn State

The Wildcats lead the Big Ten in red zone offense with a 92 percent conversion rate (13 TDs), while the Nittany Lions are tops in red zone defense (61 percent, six TDs).

No. 25 UCLA at California

The Bruins have not won at Memorial Stadium in Berkeley since 1998.

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