Redshirt freshman LaMichael James ran for 183 yards and a score as the Ducks (7-1, 5-0 Pacific-10) racked up 391 yards on the ground against the Trojans, who came into the game with the fifth-best rush defense in the nation, allowing an average of 79.9. Oregon finished with 613 yards total.

Southern Cal (6-2, 3-2) had not lost by more than a touchdown since a 27-16 loss to Notre Dame in 2001, Pete Carroll’s first season as Trojans coach. It was USC’s worst lost since a 35-7 defeat to Arizona State Oct. 11, 1997, and it was the most points allowed by the Trojans in Carroll’s tenure.

Oregon remained alone in first and undefeated in the conference, threatening USC’s hold on the league championship for the past seven years. The Ducks have won seven straight since an embarrassing 19-8 loss at Boise State in the opener, a game that got uglier when running back LeGarrette Blount punched a Broncos defensive end as he was leaving the field.

Blount was suspended for the season and James was his replacement on the first-team offense.

Oregon fans were decked out in special black “Fright Night’’ T-shirts with a duck-and-crossbones motif to commemorate the Halloween contest - billed as the Pac-10’s biggest game of the season. Afterward the fans swarmed the field, while a ring of blue-jacketed security guards circled the goal posts.

USC freshman quarterback Matt Barkley, who predicted he would feed off Autzen’s deafening noise, completed 21 of 38 passes for 187 yards and two scores. He was intercepted once.

Masoli completed 19 of 31 passes for Oregon, which had never before scored as many points against the Trojans.

Masoli scored on a 3-yard run to put the Ducks up, 10-3, late in the first quarter. USC tied it with Barkley’s 3-yard pass to Ronald Johnson early in the second.

Oregon went ahead again on Andre Crenshaw’s 1-yard scoring run. And USC tied it again at 17 on Barkley’s 4-yard pass to Damian Williams.

Masoli found Jamere Holland with a 17-yard touchdown pass to put the Ducks back up, 24-17, at the half.

From that point, USC couldn’t keep up.

James scored on a 5-yard run and fellow redshirt freshman Kenjon Barner ran for a 3-yard touchdown to make it 41-20 at the close of the third quarter. Morgan Flint had a pair of field goals, from 22 and 23 yards, to pad Oregon’s lead in the fourth quarter.