The Seminoles led, 17-0, at halftime and built their advantage to 27-0 before Manuel gave way to Trickett.

Manuel connected with Bert Reed on a 9-yard TD pass to get the Seminoles on the board in the opening quarter and hit Greg Dent in full stride on a 50-yard scoring play just before the half.

Manuel was replaced by Trickett with 7:03 left. Trickett fired a 28-yard TD pass to freshman Rashad Greene on his first play.

Virginia Tech 66, Appalachian St. 13 - David Wilson ran for 162 yards and three scores, Logan Thomas threw the first two TD passes of his career, and the 13th-ranked Hokies routed the Mountaineers in Blacksburg, Va.

Wilson scored on runs of 20, 19, and 3 yards - the first just 47 seconds into the game after Antone Exom recovered a fumble DeAndre Presley at the 20. Wilson also broke off runs of 48 and 33 yards before yielding to reserves in the third quarter.

The Hokies honored Frank Beamer before the game for entering his 25th season as the head coach and then announced at halftime that he’d signed a contract extension to keep him on the job through 2016.

North Carolina 42, James Madison 10 - Bryn Renner threw for 277 yards and two TDs in his first start, helping the host Tar Heels give Everett Withers a win in his debut as interim coach.

Clemson 43, Troy 19 - Tajh Boyd was 20 of 30 for 264 yards and three touchdowns in his debut as the Tigers’ starting quarterback, leading them to an easy win over the visiting Trojans.

N.C. State 43, Liberty 21 - T.J. Graham returned a punt 82 yards for a TD, James Washington rushed for two scores, and the Wolfpack pulled away for the victory in Raleigh, N.C.

Virginia 40, William & Mary 3 - Kevin Parks rushed for 114 yards and three TDs and Robert Randolph kicked four field goals as the Cavaliers rolled at home.

Richmond 23, Duke 21 - Garrett Turner rushed for a 1-yard score on fourth down with 10:12 left to help the visiting Spiders of the Championship Subdivision beat the Blue Devils for the third time in the last six seasons.