Quinn Cook scored a career-high 27 points and No. 1 Duke held Clemson to its lowest-scoring half in 12 years in a 68-40 victory over the Tigers Tuesday night in Durham, N.C.

Ryan Kelly added 12 points in the first half but sat out the second with what team officials said was a right leg injury.

The Blue Devils (15-0, 2-0 Atlantic Coast Conference) shot 48 percent, built a 42-31 rebounding advantage and pulled away down the stretch to improve to 58-4 at home against the Tigers.

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Devin Booker had 12 points and 15 rebounds for Clemson (8-6, 0-2), which had season lows for points and shooting percentage (28 percent) and shot 12 percent in its brutal first half.

The Tigers had just 10 points at halftime, their fewest since scoring 9 against Wake Forest in 2001.

Still, Clemson made things interesting briefly in the second half, closing to 34-22 on Adonis Filer’s layup with 15½ minutes left.

That came after Duke’s third consecutive turnover in the backcourt, and had an incensed coach Mike Krzyzewski thrusting his fist on the court as he called a timeout.

Tyler Thornton rattled in a 3-pointer two possessions later, and Seth Curry followed with a jumper to push it to 39-22 and put Duke back in control. Clemson didn’t get closer than 14 points the rest of the way.

Mason Plumlee finished with 13 rebounds — his ACC-leading 10th double-figure rebounding game this season — for the Blue Devils, who opened with 15 wins for the sixth time under Krzyzewski.

Missouri 84, Alabama 68 — Jabari Brown hit a career-high five straight 3-pointers after an early miss and Phil Pressey responded from a shaky first half with 11 points and 13 assists, leading the No. 10 Tigers (12-2, 1-0) over the visiting Crimson Tide (8-6, 0-1) in their SEC debut.

Trevor Releford had a career-best 26 points with three 3-pointers and topped 1,000 points for Alabama, which has lost six of eight. Coach Anthony Grant lost for the first time in seven career conference openers, three at VCU and four at Alabama.

Brown scored a career high 22 points on 7-for-11 shooting, three days after making only one of nine attempts in a 2-point victory over Bucknell. The Oregon transfer has scored in double figures four of five games since becoming eligible at the semester break.

Creighton 91, Drake 61 — Ethan Wragge matched career highs with 22 points and six 3-pointers and the No. 13 Bluejays (15-1, 4-0 Missouri Valley Conference) got off to a blistering start on its way to an easy victory over the Bulldogs (6-9, 0-4) in Omaha.

Doug McDermott added 16 points, Jahenns Manigat had 13 and Grant Gibbs 10 for the Bluejays, who won their ninth straight game.

Creighton has won 71 straight against opponents .500 or worse.

Ohio St. 74, Purdue 64 — Deshaun Thomas scored 22 points and the No. 15 Buckeyes (12-3, 2-1) shot 56.4 percent from the field in beating the host Boilermakers (7-8, 1-2), giving coach Thad Matta his 100th Big Ten victory.

The Boilermakers, who trailed by 10 at the half, were led by the Johnson brothers, Terone, who had 18 points, and Ronnie, who had 11 points, 6 rebounds, and 7 assists.

Pittsburgh 73, Georgetown 45 — Talib Zanna scored 15 points, and the visting Panthers (13-3, 1-2 Big East) rediscovered their shooting touch, hitting 55 percent from the field in an easy win over the No. 19 Hoyas (10-3, 0-2) at Washington.

Zanna went 7 for 9 from the field, Tray Woodall added 11 points and seven assists for the Panthers, who dominated the Hoyas from the opening tip to bounce back from two Big East losses that knocked them out of the Top 25.

Women

Notre Dame 75, South Florida 71 — Skylar Diggins scored 4 of her 19 points in overtime, helping the second-ranked Irish (13-1, 2-0 Big East) overcome cold shooting to hold off the host Bulls (11-3, 0-1).

Natalie Achonwa had 20 points and Jewell Loyd finished with 18 points and 13 rebounds for the Fighting Irish in their first game since handing then-No. 1 Connecticut its first loss of the season. Kayla McBride was limited to 12 points on 4-for-14 shooting, but keyed a second half surge that helped Notre Dame take its first lead since early in the game.

Louisville 66, Rutgers 57 — Antonita Slaughter drained a 3-pointer to open overtime and finished the extra frame with 6 of her 10 points as the No. 15 Cardinals (13-3, 1-1) earned their first Big East Conference win, topping the Scarlet Knights (9-6, 0-2) in Louisville, Ky.