Shane Larkin noticed during warm-ups that something was off with second-ranked Miami. The go-go, uptempo Hurricanes seemed a step slow, and not entirely ready to play.

They certainly paid for it.

Miami’s unbeaten start to Atlantic Coast Conference play is history. So is its 14-game winning streak and its highest-ever national ranking after the Hurricanes were knocked off by Wake Forest, 80-65, Saturday in Winston-Salem, N.C.

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‘‘You could just see it tonight. I had a bad feeling coming into warm-ups with everybody going slow,’’ Larkin said. ‘‘I was trying to get people to go fast, and I wasn’t even going full speed like I should have.

‘‘Overall, we weren’t prepared before the game and they came out and punched us in the mouth.’’

Durand Scott had all 17 of his points in the second half for the Hurricanes (22-4, 13-1), the last of the schools in the six BCS conferences to get its first league loss.

Miami never got closer than 11 in the final nine minutes as the best start to ACC play since Duke’s 16-0 mark in 1998-99 came to a surprisingly lopsided end.

C.J. Harris finished with 23 points and hit all five of his 3-pointers for the Demon Deacons (12-14, 5-9).

Gonzaga 81, San Diego 50 — Kevin Pangos scored 18 points and the No. 3 Bulldogs crushed the Toreros (13-16, 6-8 West Coast) in Spokane, Wash.

Gonzaga (27-2, 14-0) clinched at least a tie for the WCC regular-season title. It marks the 12th league title in 13 seasons for the Bulldogs, who set a team record for regular-season wins.

Florida 71, Arkansas 54 — Mike Rosario scored 15 points and Patric Young added 14 to pace a balanced attack that helped the No. 5 Gators (22-4, 12-2 SEC) beat the visiting Razorbacks (17-10, 8-6).

Georgetown 57, Syracuse 46 — Otto Porter scored a career-high 33 points and the No. 11 Hoyas (21-4, 11-3 Big East) beat the eighth-ranked Orange (22-5, 10-4), snapping Syracuse’s 38-game winning streak in the Carrier Dome, the longest in Division 1.

The loss came in front of a record crowd of 35,012, the largest ever to see a college basketball game on campus.

Kansas 74, TCU 48 — Jeff Withey scored 18 points, Ben McLemore added 14, and the No. 9 Jayhawks (23-4, 11-3 Big 12) routed visiting TCU to avenge a stunning loss to the lowly Horned Frogs (10-17, 1-13) just over two weeks ago.

Louisville 79, Seton Hall 61 — Gorgui Dieng scored a career-high 23 points on 10-of-11 shooting to help the No. 10 Cardinals (22-5, 10-4 Big East) top the visiting Pirates (13-15, 2-13).

Arizona 73, Washington State 56 — Kevin Parrom matched a career high with five 3 pointers — in six tries — scoring 19 points and leading the No. 12 Wildcats (23-4, 11-4 Pac-12) past the visiting Cougars (11-17, 2-13).

Kansas State 81, Texas 69 — Rodney McGruder scored 20 points as the No. 13 Wildcats (22-5, 11-3 Big 12) beat the host Longhorns.

Myck Kabongo had 24 points for Texas (12-15, 4-10), the most he’s scored in four games since returning from a 23-game NCAA suspension.

Oklahoma State 73, West Virginia 57 — Le’Bryan Nash and Markel Brown scored 16 points apiece and the 14th-ranked Cowboys (20-6, 10-4 Big 12) beat the Mountaineers (13-14, 6-8) in Morgantown, W.Va.

New Mexico 91, Colorado State 82 — Kendall Williams sank a Mountain West Conference-record 10 3-pointers on his way to a career-high 46 points, and the No. 16 Lobos (23-4, 10-2) ended the No. 22 Rams’ 27-game home winning streak.

Colton Iverson had 26 points and 15 boards for Colorado St. (21-5, 8-4).

Villanova 60, Marquette 56 — Darrun Hilliard scored 22 points as the host Wildcats (18-10, 9-6 Big East) beat the No. 17 Golden Eagles (19-7, 10-4).

Memphis 89, Southern Mississippi 73 — Memphis is leaving Conference USA with the regular-season conference crown. The No. 21 Tigers (24-3, 13-0), who will move to the Big East next season, pulled away from the visiting Golden Eagles (21-7, 10-3) in the second half for their 18th straight win.

Oregon 77, Stanford 64 — Johnathan Loyd had season highs of 15 points and nine assists to lead the No. 23 Ducks (22-6, 11-4 Pac-12) over the visiting Cardinal (16-12, 7-8), giving Oregon coach Dana Altman his 600th career win.

Virginia Commonwealth 75, Xavier 71 — Troy Daniels scored 19 points and set a school record for 3-pointers in a season as the No. 24 Rams (22-6, 10-3 Atlantic 10) intensified their full-court defense to overcome a 17-point deficit in the second half and top the host Musketeers (15-11, 8-5).

Xavier came into the game as the only team still unbeaten at home in A-10 play. VCU became only the second A-10 team to win at the Cintas Center since 2007, along with Saint Louis.