Key injuries: COWBOYS: OUT: NT Jay Ratliff (groin). QUESTIONABLE: LB Ernie Sims (concussion). PROBABLE: LB Alex Albright (knee), WR Dez Bryant (finger), LB Victor Butler (groin), DT Jason Hatcher (thigh), RB Felix Jones (knee), RB DeMarco Murray (foot), LB DeMarcus Ware (elbow, shoulder). REDSKINS: QUESTIONABLE: S DeJon Gomes (knee), T Tyler Polumbus (head).
Arizona at San Francisco
Time: 4:25 p.m. Line: 49ers by 16½.
Records: Cardinals 5-10 (6-8-1 vs. spread), 49ers 10-4-1 (9-6 vs. spread).
Comments: 49ers beat Cardinals, 24-3, Oct. 29 . . . Former Patriot QB Brian Hoyer gets his first career start for the Cardinals . . . San Fran’s Aldon Smith needs 3½ sacks to break Michael Strahan’s season record (22½) . . . 49ers are 7-0 coming off a loss or tie during the Jim Harbaugh administration . . . San Fran WR Michael Crabtree is 67 yards shy of his first 1,000-yard receiving season . . . Arizona WR Larry Fitzgerald has just 200 receiving yards in his last six games . . . Player to watch: 49ers K David Akers has at least one field goal in 32 straight games.
Key injuries: CARDINALS: OUT: WR Early Doucet (concussion). DOUBTFUL: WR LaRon Byrd (knee). QUESTIONABLE: G Mike Gibson (calf), T Nate Potter (ankle), RB Anthony Sherman (knee), DE Ronald Talley (ankle). PROBABLE: S Rashad Johnson (hamstring), S Kerry Rhodes (illness), S James Sanders (calf), CB Greg Toler (hamstring), DT Dan Williams (hamstring), S Adrian Wilson (illness). 49ERS: DOUBTFUL: DT Justin Smith (elbow, triceps). QUESTIONABLE: TE Vernon Davis (concussion), LB Clark Haggans (shoulder), DT Will Tukuafu (neck). PROBABLE: LB NaVorro Bowman (wrist, shoulder), LB Ahmad Brooks (shoulder), CB Tarell Brown (shoulder, knee), LB Tavares Gooden (illness, rib), C Jonathan Goodwin (illness), RB Frank Gore (knee), G Mike Iupati (shoulder), P Andy Lee (illness), RB Bruce Miller (shoulder), S Trenton Robinson (finger), CB Carlos Rogers (knee, toe), LB Aldon Smith (shoulder), S Donte Whitner (knee).
St. Louis at Seattle
Time: 4:25 p.m. Line: Seahawks by 10½.
Records: Rams 7-7-1 (10-5 vs. spread), Seahawks 10-5 (11-4 vs. spread).
Comments: Rams stunned Seahawks, 19-13, Sept. 30 . . . St. Louis QB Sam Bradford is 4-0-1 in last five division tilts . . . Seattle coach Pete Carroll reportedly is nursing a sore shoulder from sideline celebrations last week . . . Rams seek first winning record since 2003 . . . Seattle’s Russell Wilson is seeking to become first rookie QB to go 8-0 at home . . . Seattle RB Marshawn Lynch has two straight 100-yard efforts vs. St. Louis . . . Player to watch: Rams RB Steven Jackson is 10 rushing yards shy of becoming sixth NFLer with eight straight 1,000-yard campaigns.
Key injuries: RAMS: PROBABLE: RB Steven Jackson (foot). SEAHAWKS: OUT: CB Walter Thurmond (hamstring).
Philadelphia at NY Giants
Time: 1 p.m., Fox Line: Giants by 7.
Records: Eagles 4-11 (3-11-1 vs. spread), Giants 8-7 (6-8-1 vs. spread).
Comments: Eagles beat Giants, 19-17, Sept. 30 . . . Probable Philly swan songs for coach Andy Reid and QB Michael Vick (who will start) . . . Big Blue back Ahmad Bradshaw needs 92 rushing yards for his first 1,000-yard season.
Key injuries: EAGLES: OUT: DT Fletcher Cox (concussion), LB Mychal Kendricks (concussion). DOUBTFUL: TE Evan Moore (back). GIANTS: DOUBTFUL: CB Prince Amukamara (hamstring), DT Chris Canty (knee), CB Jayron Hosley (quadriceps).
Chicago at Detroit
Time: 1 p.m. Line: Bears by 3.
Records: Bears 9-6 (7-8 vs. spread), Lions 4-11 (5-10 vs. spread).
Comments: Bears beat Lions, 13-7, Oct. 22 . . . Chicago is 2-5 since that win over Detroit. . . Lions QB Matthew Stafford is seven attempts shy of breaking Drew Bledsoe’s season mark (691).
Key injuries: BEARS: OUT: S Chris Conte (hamstring), LB Blake Costanzo (calf). DOUBTFUL: LB Brian Urlacher (hamstring). LIONS: OUT: DT Sammie Hill (toe). DOUBTFUL: TE Brandon Pettigrew (ankle).
Baltimore at Cincinnati
Time: 1 p.m. Line: Bengals by 2½.
Records: Ravens 10-5 (6-8-1 vs. spread), Bengals 9-6 (8-6-1 vs. spread).
Comments: Ravens pounded Bengals, 44-13, Sept. 10 . . . Teams would meet for a third time next weekend if Baltimore secures No. 3 seed . . . Bengals have won 6 of last 7 games.
Key injuries: RAVENS: QUESTIONABLE: WR Anquan Boldin (shoulder). BENGALS: QUESTIONABLE: CB Jason Allen (hamstring), CB Terence Newman (groin).
Tampa Bay at Atlanta
Time: 1 p.m. Line: Falcons by 5.
Records: Buccaneers 6-9 (8-5-2 vs. spread), Falcons 13-2 (9-5-1 vs. spread).
Comments: Falcons edged Buccaneers, 24-13, Nov. 25 . . . Atlanta is 20-0 at home when Matt Ryan has a 100-plus passer rating . . . Josh Freeman is 157 passing yards shy of becoming first Bucs QB with a 4,000-yard season. Continued...