SAN FRANCISCO — Andrew Luck faked out the defense, ran untouched into the end zone for a 6-yard touchdown, and emphatically threw down the ball with a little extra oomph.
Even he thought it might be a career-best spike.
‘‘It was nice to score,’’ he said matter-of-factly of the moment.
Jim Harbaugh’s former quarterback sure outplayed his current one, and it wasn’t even close.
Luck passed for 164 yards while facing college coach Jim Harbaugh for the first time, and the Indianapolis Colts defeated the San Francisco 49ers, 27-7, on Sunday.
Trent Richardson scored a 1-yard touchdown on his first carry in his Colts debut after being acquired last Wednesday from the Browns. He was drafted two spots behind top-pick Luck last year. Full story for BostonGlobe.com subscribers.