NFL update

Week 6's key matchups:

Line: Colts by 4. Comments: The Colts, who used to live in Baltimore, are 5-2 vs. current residents . . . Actually, the Colts might want to move back. They've lost four straight home games . . . Ravens haven't allowed a 100-yard rusher in 23 straight games . . . Willis McGahee, start your engine: Colts have the worst rushing defense in the league (188.5) . . . Peyton Manning, start your engine: Ravens' pass defense is ranked No. 31 . . . Manning needs 383 yards to pass Dan Fouts (43,040) for eighth on all-time list . . . Colts have won 12 consecutive games in October . . . Indy has allowed just seven sacks . . . Baltimore LB Ray Lewis has 74 tackles in six career games vs. Colts.

Key injuries: RAVENS: OUT: S Dawan Landry (neck), CB Samari Rolle (neck, shoulder), CB Fabian Washington (shoulder). DOUBTFUL: T Adam Terry (knee). COLTS: OUT: WR Roy Hall (knee), CB Kelvin Hayden (knee), CB Bob Sanders (knee).

Line: Buccaneers by 1 1/2. Comments: Jeff Garcia is back as Buccaneers starting QB but Jon Gruden reserves the right to bring Steve DeBerg back at halftime . . . Panthers have won five straight in Tampa and eight of last 10 in rivalry . . . Tampa bruiser Earnest Graham has rushed for at least 100 yards in five straight games at Raymond James Stadium . . . Bet you didn't know career journeyman Antonio Bryant (24 receptions) is Tampa's top receiver . . . Panther QB Jake Delhomme is 7-1 vs. Bucs . . . Carolina's Julius Peppers has 11 sacks in 11 games vs. Tampa Bay . . . Panther receiver Muhsin Muhammad is enjoying a revival season with 25 catches for 358 yards and a pair of TDs.

Key injuries: PANTHERS: DOUBTFUL: WR D.J. Hackett (knee), C Ryan Kalil (ankle). BUCCANEERS: OUT: RB B.J. Askew (hamstring), WR Joey Galloway (foot).

Line: Broncos by 3 1/2. Comments: Broncos are bucking for the 400th win in franchise history . . . Denver will miss leading rusher Selvin Young (5.7 yards per game) . . . Jaguars' normally stout defense allowed 415 yards in loss to Steelers last week . . . Jacksonville QB David Garrard didn't throw an interception in his first eight starts last season, but has thrown at least one in the last four games . . . Jags receiver Mike Walker set a career high with 6 receptions for 107 yards last week . . . Denver is averaging 29.8 points per game . . . Broncos K Matt Prater is 4 for 4 from 50-plus yards this season.

Key injuries: JAGUARS: OUT: C Brad Meester (biceps), S Reggie Nelson (knee), WR Mike Walker (knee) DOUBTFUL: DT Rob Meier (knee), G Chris Naeole (knee). BRONCOS: OUT: TE Tony Scheffler (groin), RB Ryan Torain (elbow), RB Selvin Young (groin).

Line: Cowboys by 4 1/2. Comments: Poor Pacman Jones. Why do people keep picking on this man? . . . Cardinals have at least one sack in 28 straight games, longest streak in the NFL . . . Dallas has the league's No. 3 offense, while Arizona checks in at No. 5 . . . Cowboys combo of Tony Romo and Terrell Owens has 30 TD connections since 2006 . . . Another Cowboy combo, RBs Marion Barber (395) and Felix Jones, has combined for 639 yards . . . Arizona QB Kurt Warner can still zing it (1,472 yards, 10 TDs), and his favorite target is the electric Larry Fitzgerald (31 catches, 4 TDs) . . . Cardinals lead their division after five games for first time since 1988.

Key injuries: COWBOYS: OUT: G Kyle Kosier (foot), CB Terence Newman (abdomen), S Pat Watkins (neck), S Roy Williams (forearm). CARDINALS: OUT: WR Anquan Boldin (head). DOUBTFUL: TE Ben Patrick (knee).

Other games this week:

Line: Redskins by 13. Comments: Jim Haslett Era begins in St. Louis. Good luck, Jim. Rams have lost eight straight . . . Speaking of good luck, Jim: Redskins rookie coach Jim Zorn has his team off to a 4-1 start . . . Washington QB Jason Campbell has gone 175 attempts without a pick.

Key injuries: RAMS: OUT: WR Drew Bennett (foot), CB Tye Hill (knee), WR Dane Looker (concussion), RB Antonio Pittman (lower leg). DOUBTFUL: WR Keenan Burton (knee). REDSKINS: OUT: S Reed Doughty (back).

Line: Jets by 9. Comments: No truth to the rumor that Bruce Coslet will deliver pregame speeches to each club . . . Jets will wear New York Titans uniforms for second straight game . . . Jets QB Brett Favre leads NFL with 12 TDs and a 110.8 passer rating . . . Bengal WR T.J. Houshmandzadeh has 31 catches.

Key injuries: BENGALS: OUT: LB Corey Mays (ankle). DOUBTFUL: QB Carson Palmer (right elbow). JETS: OUT: WR David Clowney (shoulder), K Mike Nugent (right thigh).

Line: Saints by 7. Comments: The Tom Cable Era begins in Oakland. Good luck, Tom. You're going to need it . . . Saints RB Reggie Bush needs one reception to tie Anquan Boldin as the fastest to 200 (34 games) . . . Nawlins QB Drew Brees has thrown for 2,531 yards and 16 TDs in last eight games at Superdome . . . Raider QB JaMarcus Russell was sacked six times in last game.

Key injuries: RAIDERS: DOUBTFUL: DE Derrick Burgess (triceps). SAINTS: OUT: DT Sedrick Ellis (knee), CB Aaron Glenn (ankle), DT Antwan Lake (groin). DOUBTFUL: S Kevin Kaesviharn (back), WR David Patten (groin), TE Jeremy Shockey (hernia).

Line: Vikings by 13. Comments: Lions' four losses have come by an average of more than 20 points . . . Gus Frerotte, who will start for Minnesota, was last QB to lead Detroit to the postseason (1999) . . . Vikings have won 10 straight in dome vs. Lions . . . Former UConn QB Dan Orlovsky could get start for Lions.

Key injuries: LIONS: DOUBTFUL: QB Jon Kitna (back), G Stephen Peterman (hand). VIKINGS: DOUBTFUL: S Madieu Williams (neck).

Line: Texans by 3. Comments: Joey Porter leads the revitalized Dolphin defense with 4 1/2 sacks in his last two games . . . Houston QB Matt Shaub is 29 yards shy of 4,000 for his career . . . Texan LB Zac Diles (yeah, he's a real person) has a team-high 36 tackles . . . Miami RB Ronnie Brown has two straight 100-yard games.

Key injuries: DOLPHINS: QUESTIONABLE: LB Reggie Torbor (hip). TEXANS: OUT: LB Dominique Barber (hamstring), TE Mark Bruener (hamstring), RB Chris Taylor (quadriceps).

Line: Bears by 3. Comments: Both teams' losses have come against the Buccaneers and Panthers . . . Chicago's Kyle Orton (334 yards) and Atlanta's Matty "Ice" Ryan (194) set career highs in passing yards last week . . . Falcons RB Michael Turner (543 yards) leads all NFL rushers . . . Bears rookie RB Matt Forte has 555 total yards.

Key injuries: BEARS: DOUBTFUL: WR Brandon Lloyd (knee). FALCONS: DOUBTFUL: DT Jason Jefferson (ankle), WR Laurent Robinson (knee).

Line: Eagles by 4 1/2. Comments: Eagles QB Donovan McNabb needs just 12 attempts and 264 passing yards to become franchise leader. Ron Jaworski (who is terrific on ESPN, by the by) holds both marks . . . Eagles have won two straight at Candlestick . . . 49er Frank Gore leads NFL in yards from scrimmage (603).

Key injuries: EAGLES: OUT: G Shawn Andrews (back), WR Reggie Brown (groin), S J.R. Reed (hamstring, ankle), RB Brian Westbrook (rib, ankle). 49ERS: OUT: T Jonas Jennings (shoulder), CB Shawntae Spencer (knee). DOUBTFUL: LB Manny Lawson (hamstring).

Line: Seahawks by 1.

Comments: Packers have lost three straight but are 12-6 on the road under Mike McCarthy . . . Green Bay's Aaron Rodgers has five TD passes of 20 or more yards . . . Seattle boss Mike Holmgren, the former Packer boss, is 2-4 against Green Bay . . . Seahawks' Matt Hasselbeck, a former Packer backup, has completed just 49.2 percent of his passes.

Key injuries: PACKERS: OUT: CB Al Harris (spleen). DOUBTFUL: S Atari Bigby (hamstring), DE Jason Hunter (hamstring), DE Mike Montgomery (ankle). SEAHAWKS: QUESTIONABLE: WR Deion Branch (heel), QB Matt Hasselbeck (knee), QB Seneca Wallace (calf).

Line: Giants by 7 1/2.

Comments: Giants setting the pace in the NFL at 31.7 points per game . . . Brownies clicking for just 11.5 points per game (31st in NFL) . . . This is Cleveland's first "Monday Night Football" appearance since 2003 . . . Jints, who welcome Plaxico Burress back after one-game suspension, have won 11 straight road tilts.

Key injuries: GIANTS: QUESTIONABLE: LB Antonio Pierce (quadriceps). BROWNS: QUESTIONABLE: S Sean Jones (knee), T Kevin Shaffer (concussion), DE Shaun Smith (hand), G Ryan Tucker (hip), TE Kellen Winslow (illness).