Clark ranked third on the team with 37 catches for 347 yards after catching 100 passes for 1,106 yards and 10 touchdowns last season, when he made the All-Pro team. The Colts did not say how or when Clark was hurt, but he appeared to grab at his left wrist during a play in the Oct. 17 win at Washington.

Clark, 31, and quarterback Peyton Manning have developed into one of the most prolific quarterback-tight end combinations in NFL history. Earlier this season, they connected on their 44th touchdown pass, second only to Drew Bledsoe and Ben Coates (45).

Minnesota defensive end Ray Edwards was fined the most, $20,000, for spearing Dallas running back Marion Barber. Edwards was cited as a repeat offender; he was fined Aug. 28 for roughing the passer and Sept. 26 for unnecessary roughness.

“I just got fined $20,000 for a spear that really wasn’t a spear,’’ Edwards said. “If you look at the last play, [Dallas tackle Marc] Colombo speared Jared [Allen] and I don’t believe he got fined. If you’re going to fine people, fine everybody. Don’t just fine defensive guys.’’

The league did not fine Colombo.

Earlier this week, huge fines were given for flagrant fouls by Pittsburgh’s James Harrison ($75,000), Atlanta’s Dunta Robinson, and the Patriots’ Brandon Meriweather (both $50,000). The league also promised suspensions for players who make illegal hits on defenseless opponents.

The 15 fines were unusually high for one week, a signal of the NFL’s resolve to police violent play. Generally, either a $5,000 or $10,000 fine is handed out for roughness. In this week’s total all but two were for roughness.

Included in the latest penalties:

■New Orleans cornerback Malcolm Jenkins was fined $10,000 for two hits, one to the head area of Tampa Bay quarterback Josh Freeman and one out of bounds.

■Tennessee defensive end William Hayes was fined $10,000 for a late hit, while teammate Dave Ball was given a $5,000 fine for roughing the passer with a hit to the head or neck area against Jacksonville.

■Three Houston players were fined $5,000: guard Wade Smith for a leg whip, defensive end Adewale Ogunleye for a late hit on Kansas City quarterback Matt Cassel, and safety Bernard Pollard for hitting a Chiefs player out of bounds.

■Philadelphia quarterback Kevin Kolb was fined $5,000 for a horse-collar tackle on Atlanta’s William Moore while Moore was returning an interception. It is believed to be the first time a quarterback has been fined for the offense.

Harrison, who threatened to retire after the NFL’s crackdown, was fined for his tackle of Browns receiver Mohamed Massaquoi, who suffered a concussion. Harrison also had a hard hit on former Kent State teammate Joshua Cribbs.

Cribbs told his friend not to change the way he plays, and that Harrison’s job is to simply “knock people out.’’

“You’re a player, so play,’’ Cribbs said he told Harrison. “Let refs ref. Let the NFL administration, let everyone do their jobs. If you get fined, just try to tailor yourself, but play the game. Don’t try to change who you are.’’

Cribbs returned to practice yesterday for the first time since suffering a concussion when he was knocked out last Sunday by Harrison.

Starting defensive tackle Kyle Williams is questionable to play at Baltimore tomorrow, leaving the winless Bills already porous run defense with a big hole to fill. Williams missed his second straight practice because of a bruised bone and an inflamed ligament in his left ankle. He was hurt when a teammate rolled up on his leg in practice Wednesday. Buffalo’s allowed a league-worst 912 rushing yards, 15 more than Oakland even though the Raiders have played one extra game . . . The Packers may have sacks leader Clay Matthews back for tomorrow night’s game against Minnesota after he missed last week’s loss to Miami with a hamstring injury . . . The NFL still is investigating allegations that Vikings quarterback Brett Favre sent lewd photos and inappropriate text messages to a New York Jets game hostess two years ago, with the door open to a conversation between the woman and league officials.