The Patriots held a 21-0 lead over the Bills midway through the second quarter of last year's matchup. Four Tom Brady interceptions later, the Bills came out on top, 34-31, in a wild finish. It was their first loss to the Bills in 16 games since the 2003 regular season opener. The two teams face off again Sunday, the first of two scheduled affairs this season. Here's a look at some of Sunday's most intriguing matchups.