Brady to Welker
With four minutes remaining in Super Bowl XLVI and the Patriots up, 17-15, Tom Brady threw a pass to Wes Welker on second-and-11 that was too hot for Welker to handle. The ball was slightly behind Welker, but went through his hands, and no matter whom you place the blame on, the miscue was big enough to prevent New England from going deep into Giants territory with the chance to put the game way.
That play more than any other represented the missed opportunity of the game, which would have given Brady his fourth Super Bowl ring in five tries.
Honorable mention here goes to Brady's first-quarter intentional grounding penalty, which resulted in a safety and the first two points of the game for New York.