10: Patriots vs. Saints
Date: Sunday, Oct. 13, at 4:25 p.m. ET
Compelling story line: Tom Brady is going for Drew Brees's record for consecutive games with a touchdown pass (54). With 48 consecutive games to his name, Brady could potentially tie Brees's record in this game.
The last time these teams met, in 2009, the Saints blew the doors off the Patriots in the Superdome as part of a 13-game win streak to start the season on their way to the Super Bowl. These teams are familiar with each other on a more recent basis than that, as they practiced together in the 2010 and 2012 training camps for a week, leading up to preseason games.
Interesting stat: Drew Brees is 3-0 against the Patriots, and has completed 72.3 percent of his passes with eight touchdowns, no interceptions, and a 148.3 passer rating.
Bold prediction: The Patriots and Saints will combine for over 70 points.