5: Dolphins vs. Colts
Date: Sunday, Sept. 15, at 1 p.m. ET
Compelling story line: This is Ryan Tannehill vs. Andrew Luck Part 2, with Luck's Colts coming out on top, 23-20, in the first meeting. With the first overall pick in the 2012 draft against the eighth overall pick, this quarterback duel could come to define the AFC in years to come. Either way, this game could go a long way in deciding which of these two teams makes it to the playoffs as a wild card.
Interesting stat: According to ProFootballFocus.com, Andrew Luck went downfield (20 yards or more) on 16.1 percent of his throws—third-most in the league—in 2012. The Dolphins gave up 60 passing plays of 20 yards or more, fourth-most in the league.
Bold prediction: Former Dolphin cornerback Vontae Davis will log an interception of Ryan Tannehill.