The Patriots will be without left guard Logan Mankins against the Bills Sunday - he did not make the trip here to Buffalo.
Mankins popped up on the injury report last Thursday before the Ravens game with a hip injury, but he did play last Sunday night.
However, Mankins did not practice at all this week, making it almost a certainty that he wouldn't play. But if there was ever a player Bill Belichick would let sit out three days of practice and still play in a game, it would be tough-as-nails Mankins.
Now it is clear he is too hurt to play, at least this week.
Not having Mankins is a big blow for the offensive line, particularly against the Bills' talented defensive line. Tackles Kyle Williams and Marcel Dareus are a lot for interior O-linemen to handle, and now New England will be without its best lineman.
UPDATE (9:30 p.m.) - The Patriots have announced that DLs Brandon Deaderick (ankle) and Justin Francis (ankle) and CB Alfonzo Dennard (hamstring) have also been downgraded to out.
Rob Gronkowski, who was on the report for the first time this season on Friday, also with a hip injury, did make the trip. He is listed as questionable.
New England is expected to officially announce its downgrades around 9 p.m.